The most widely prescribed PPA (Phenylpropanolamine) in the world for fast, effective management of urinary incontinence in dogs.
DESCRIPTION:
Propalin is a PPA with proven efficacy, rapid bioavailability and is clinically proven safe. It is a sympathomimetic, non-hormonal agent that is manufactured and distributed in compliance with all US DEA regulations concerning a Class 1 chemical.
METHOD OF ACTION:
Propalin safely and effectively manages urinary incontinence due to Urethral Sphincter Mechanism Incompetence (USMI) to help improve quality of life and preserve the pet-owner bond.
- Works by stimulating the alpha adrenergic receptors in the urethral muscle
- Increases sphincter tone and the bladder's ability to retain urine
- The only PPA product with documented efficacy
FORMULATION(S):
Easy to administer chewable tablets in convenient sizes for easy dosing:
- 25 mg (60 tablets)
- 50 mg (60 tablets)
- 50 mg (180 tablets)
- 75 mg (60 tablets)
The active ingredient in Propalin is readily and completely absorbed from the gastro-intestinal tract, with peak plasma concentration being achieved in one to two hours after oral administration. The steady state serum concentration is reached after two days of treatment, and pet owners see a noticeable improvement typically within the first week.
- 75-90% of dogs respond positively to treatment
- Rapid improvement, usually within first week
- Improvement maintained over time
DOSING AND TREATMENT:
Propalin is available in tasty, chewable tablets that are conveniently scored and easier to administer than capsules. Propalin should be divided into two or three equal daily doses according to body weight and administered orally with food.
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References:
- Richter, P.R. and Ling, G.V. Clinical response and urethral pressure profile changes after phenylpropanolamine in dogs with primary sphincter incompetence. JAVMA 1985; 187: 605-611.
- Propalin Product Profile 1999.
- Leddy, M.C., Weaver, J. and Eyett-Burton, C. Long-term study of phenylpropanolamine in the control of urinary incontinence in the bitch.
- Scott L. Evaluation of the clinical efficacy of phenylpropanolamine in a placebo controlled trial in the control of urinary incontinence in the bitch. Journal of Small Animal Practice 2002; 43: 493-496.
- Chew, D. Fixing the dripping in senior female dogs. North American Veterinary Conference Proceedings 2004; 445-447.
